Laboratory Services

Alpha-1-Antitrypsin, Serum

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Updated Test Information:

Test Description
Alpha-1-Antitrypsin, Serum
Synonym(s)

Alpha 1 Antitrypsin; Anti-Alpha-1-Trypsin; Prolastin; A1A; AAT (Alpha-1-Antitrypsin); Alpha-1-Antitrypsin Reflex; AAT

Test ID
AAT
General Information

Useful for:



  • Workup of individuals with suspected disorders such as familial chronic obstructive lung disease

  • Diagnosis of alpha-1-antitrypsin deficiency

Specimen Type

Serum

Specimen Requirements

  • Preferred: Red Top

  • Acceptable: Serum Gel

Stability

  • Refrigerated (preferred): 28 days

  • Ambient: 28 days

  • Frozen: 28 days

Unacceptable Specimen Conditions

Gross Lipemia

Limitations

  • Low alpha-1-antitrypsin (A1A) levels may result from liver disease, and A1A proteotyping should be done to confirm A1A deficiency disease.

  • A1A is an acute-phase reactant and any inflammatory process will elevate serum A1A levels.

  • Quantitation of specific proteins by nephelometric means may not be possible in lipemic sera due to the extreme light scattering properties of the specimen. Turbidity and particles in the specimen may result in extraneous light scattering signals, resulting in variable specimen analysis.

Methodology

Nephelometry

Estimated TAT

1-2 days

Testing Schedule

Monday - Friday

Test Includes

Alpha-1-Antitrypsin, S

Retention

14 days

CPT Code(s)

82103

Additional Information
Minimum Sample Volume

0.5 mL

Reference Range

100 - 190 mg/dL

Performing Lab

Mayo

LOINC Code(s)

6771-0