Laboratory Services

Antimitochondrial (M2) Antibody

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Updated Test Information:

Test Description
Antimitochondrial (M2) Antibody
AMA, Mitochondrial Antibody
Test ID
General Information
Antimitochondrial antibodies are important diagnostic indicators for patients with Primary Biliary Cirrhosis (PBC), chronic active hepatitis, cryptogenic cirrhosis, as well as in those with clinical but no biochemical evidence of liver disease. The mitochondrial M2 antigen has a 95% specificity for PBC. Assay results should be used in conjunction with clinical findings and other serological tests.
Specimen Type
Alternate Specimen Type
Plasma (Li-Heparin or EDTA)
Specimen Requirements
Additional Processing Details
Caution: Serum/plasma samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.
Stored at 22˚C: 8 hrs
Stored at 2-8˚C: 48 hrs
If assays are not completed within 48 hrs or the specimen is to be stored beyond 48 hrs, the serum/plasma should be frozen at or below -20˚C.
Unacceptable Specimen Conditions
Lipemic, hemolyzed or microbially contaminated samples.
Fluorescent enzyme immunoassay (FEIA)
Estimated TAT
2-5 days
Testing Schedule
Monday-Saturday, alternating days
CPT Code(s)
Minimum Sample Volume
1 mL
Pediatric Min. Volume (if applicable)
500 uL
Reference Range
  Negative Equivocal Positive
Antimitochondrial (M2) AB <4 4-6 >6  U/ml
Performing Lab
Incyte Diagnostics
LOINC Code(s)