Laboratory Services

Antiphospholipid Syndrome Panel

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Updated Test Information:

Test Description
Antiphospholipid Syndrome Panel
Synonym(s)

APS, Cardiolipin, Beta-2 Glycoprotein 1

Test ID
APS
General Information

Patients with antiphospholipid syndrome (APS) have an increased risk for stroke, myocardial infarction, venous thrombosis, thromboembolism, thrombocytopenia, and/or recurrent miscarriages. The detection of cardiolipin and beta-2 glycoprotein 1 antibodies are useful serological markers for APS. Assay results should be used in conjunction with clinical findings and other serological tests.

Specimen Type

Serum

Alternate Specimen Type

Plasma (Li-Heparin, EDTA, or Citrate)

Specimen Requirements

Tiger

Additional Processing Details

Caution: Serum/plasma samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.

Stability

Store at 22˚C: 8 hrs
Store at 2-8˚C: 1 week
If assays are not completed within 1 week or the specimen is to be stored beyond 1 week, the serum/plasma should be frozen at or below -20˚C.

Unacceptable Specimen Conditions

Lipemic, hemolyzed or microbially contaminated samples.

Methodology

Fluorescent enzyme immunoassay (FEIA)

Estimated TAT

2-5 days

Testing Schedule

Monday-Saturday, alternating days

Test Includes

Cardiolipin IgA
Cardiolipin IgG
Cardiolipin IgM
Beta-2 Glycoprotein 1 IgA
Beta-2 Glycoprotein 1 IgG
Beta-2 Glycoprotein 1 IgM

CPT Code(s)

86146x3
86147x3

Minimum Sample Volume

1.5 mL

Pediatric Min. Volume (if applicable)

750 uL

Reference Range
  Negative Weak Pos Positive     
Cardiolipin AB, IgG <10 10-40 >40  GPL-U/ml
Cardiolipin AB, IgM <10 10-40 >40  MPL-U/ml
  Negative Equivocal Positive       
Cardiolipin AB, IgA <14 14-20 >20  APL-U/ml
Beta-2 Glycoprotein 1 AB, IgA <7 7-10 >10  U/ml
Beta-2 Glycoprotein 1 AB, IgG <7 7-10 >10  U/ml
Beta-2 Glycoprotein 1 AB, IgM <7 7-10 >10  U/ml
Performing Lab

Incyte Diagnostics

LOINC Code(s)

5076-5, 3181-5, 3182-3, 44447-1, 44448-9, 44449-7