Centrifuge blood collection tube per collection tube manufacturer's instructions
Pour off serum into aliquot tube
Freeze serum immediately, and ship specimen frozen on dry ice only
If shipment will be delayed for more than 24 hours, freeze serum at -20 to -80 ^C (up to 42 days) until shipment on dry ice.
Frozen (preferred): 42 days
Refrigerated: 72 hours
Except for immunocompromised patients or patients with suspected acute hepatitis, laboratory evaluation of hepatitis C virus (HCV) infection status should begin with HCV serologic testing, including testing for the presence of HCV antibodies (See Hepatitis C: Testing Algorithm for Screening and Diagnosis in Special Instructions.). A diagnosis of chronic HCV infection should not be based solely on the presence of detectable or quantifiable HCV RNA in a single serum specimen
An "Undetected" HCV RNA test result with a "Reactive" HCV antibody screen result may be due to 1) a falsereactive HCV antibody screen result; 2) resolved or past HCV infection; or 3) transient low viremia (ie, episodic viral replication) of active HCV infection. To distinguish between the first 2 conditions, another HCV antibody test (eg, HCCAD / Hepatitis C Virus Antibody Screen for Cadaveric or Hemolyzed Specimens, Serum) can be requested. To distinguish between the latter 2 conditions, patients should be retested for HCV RNA in 1 to 2 months, as clinically indicated.