Laboratory Services

Monoclonal Protein Study, Expanded Panel, Serum

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Updated Test Information:

Test Description
Monoclonal Protein Study, Expanded Panel, Serum
Synonym(s)
MPSS Expanded Panel
Test ID
MPSEX
General Information
Useful for:
Diagnosis of monoclonal gammopathies
Eliminating the need for urine monoclonal studies as a part of initial diagnostic studies (ie, rule-out monoclonal gammopathy)
Assessing risk of progression from monoclonal gammopathy of undetermined significance to multiple myeloma
Specimen Type
Serum
Specimen Requirements
SST
Additional Processing Details
1.5 mL
Stability
Refrigerated (preferred) 14 days
Frozen 14 days
Ambient 72 hours
Unacceptable Specimen Conditions
Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK
Methodology
TPE: Biuret
ELP: Agarose Gel Electrophoresis
IMFX: Immunofixation
KFLC, LFLC, KLR: Nephelometry
Estimated TAT
1-3 days
Testing Schedule
Monday-Saturday
Test Includes
TPE Total Protein
ELP Protein Electrophoresis
IMFX Immunofixation
KFLC Kappa Free Light Chain
LFLC Lambda Free Light Chain
KLR Kappa/Lambda FLC Ratio
CPT Code(s)
83883x2
84155
84165
86334
Reference Range

PROTEIN, TOTAL
> or =1 year: 6.3-7.9 g/dL
Reference values have not been established for patients that are <12 months of age.

PROTEIN ELECTROPHORESIS
Albumin: 3.4-4.7 g/dL
Alpha-1-globulin: 0.1-0.3 g/dL
Alpha-2-globulin: 0.6-1.0 g/dL
Beta-globulin: 0.7-1.2 g/dL
Gamma-globulin: 0.6-1.6 g/dL
An interpretive comment is provided with the report.

IMMUNOFIXATION
No monoclonal protein detected

KAPPA-FREE LIGHT CHAIN
0.33-1.94 mg/dL

LAMBDA-FREE LIGHT CHAIN
0.57-2.63 mg/dL

KAPPA/LAMBDA-FREE LIGHT-CHAIN RATIO
0.26-1.65

Performing Lab
Mayo
LOINC Code(s)
74665-1, 80515-0, 80517-6, 80516-8, 2885-2, 2862-1, 2865-4, 2868-8, 2871-2, 2874-6, 44429-9, 33358-3, 49296-7