Laboratory Services

Myeloperoxidase Antibody

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Updated Test Information:

Test Description
Myeloperoxidase Antibody
MPO, ANCA, Antineutrophil cytoplasmic autoantibodies
Test ID
General Information
Myeloperoxidase (MPO) antibodies are useful in the diagnosis and disease management of patients with primary systemic small vessel vasculitides. Elevated levels of MPO are found during active phases of the disease and lower during remission. Assay results should be used in conjunction with clinical findings and other serological tests.
Specimen Type
Alternate Specimen Type
Plasma (Li-Heparin, EDTA, or Citrate)
Specimen Requirements
Additional Processing Details
Caution: Serum/plasma samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.
Stored at 22˚C: 8 hrs
Stored at 2-8˚C: 48 hrs
If assays are not completed within 48 hrs or the specimen is to be stored beyond 48 hrs, the serum/plasma should be frozen at or below -20˚C.
Unacceptable Specimen Conditions
Lipemic, hemolyzed or microbially contaminated samples.
Fluorescent enzyme immunoassay (FEIA)
Estimated TAT
2-5 days
Testing Schedule
Monday-Saturday, alternating days
CPT Code(s)
Minimum Sample Volume
1 mL
Pediatric Min. Volume (if applicable)
500 uL
Reference Range
Negative < 3.5 U/mL
Equivocal 3.5-5.0 U/mL
Positive > 5.0 U/mL
Performing Lab
Incyte Diagnostics
LOINC Code(s)