Test Directory

Vasculitis (ANCA) Panel

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Updated Test Information:

Test Description
Vasculitis (ANCA) Panel
Synonym(s)
Antineutrophil cytoplasmic autoantibodies, MPO, PR3, GBM, Goodpasture Syndrome
Test ID
VASCULITIS
General Information
Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies found in patients with primary systemic small vessel vasculitides associated diseases such as Wegener granulomatosis (WG), microscopic polyangiitis (MPA), Anti-GBM (Goodpasture’s syndrome) and eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome). ANCA’s have been found to be useful in diagnosing and monitoring inflammatory activity in suspected vascular diseases. Assay results should be used in conjunction with clinical findings and other serological tests.
Specimen Type
Serum
Alternate Specimen Type
Plasma (Li-Heparin, EDTA, or Citrate)
Specimen Requirements
Tiger
Additional Processing Details
Caution: Serum/plasma samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.
Stability
Stored at 22˚C: 8 hrs
Stored at 2-8˚C: 48 hrs
If assays are not completed within 48 hrs or the specimen is to be stored beyond 48 hrs, the serum/plasma should be frozen at or below -20˚C.
Unacceptable Specimen Conditions
Lipemic, hemolyzed or microbially contaminated samples.
Methodology
Fluorescent enzyme immunoassay (FEIA)
Estimated TAT
2-5 days
Testing Schedule
Monday-Saturday, alternating days
Test Includes
Myeloperoxidase Antibody
Proteinase 3 Antibody
Glomerular Basement Membrane Antibody
CPT Code(s)
83516x3
Minimum Sample Volume
1.5 mL
Pediatric Min. Volume (if applicable)
750 uL
Reference Range
  Negative Equivocal Positive               
Myeloperoxidase AB <3.5 3.5-5.0 >5.0 U/ml
Proteinase 3 AB <2.0 2.0-3.0 >3.0 U/ml
Glomerular Basement Membrane AB <7 7-10 >10 U/ml
Performing Lab
Incyte Diagnostics
LOINC Code(s)
6969-0, 6968-2, 49774-3