Positive in benign and malignant T-lymphocytes. Also expressed in approx. 30% of B-cell lymphomas, but not in benign B-cells. Therefore, co-expression with CD20 strongly suggests B-Lymphoma. Also useful in separating small B lymphocytic and mantle cell lymphomas (usually positive) from marginal zone (MALT) and follicular center cell lymphomas (usually negative).
Formalin-fixed, paraffin-embedded tissue blocks (FFPE). If tissue blocks are not available, unstained slides are acceptable (please submit 1-2 slides per antibody to be tested, cuts must be 4 microns thick).
Tissue removed during a surgical procedure and placed in 10% NBF soon after removal from the patient. Appropriate tissue for requested staining.
Complete the Incyte Diagnostics requisition with the patient's demographics and relevant clinical history.
Slides or paraffin blocks with no tissue remaining. Samples fixed in fixatives other than 10% neutral buffered formalin. Paraffin blocks that have been overheated or frozen.
IHC, Ventana Ultra Stainer
*The listed CPT codes are for reference use only. Final coding is based on CPT guidelines and individual circumstances.