Test Directory

17-Hydroxypregnenolone, Serum

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Updated Test Information:

Test Description
17-Hydroxypregnenolone, Serum
Synonym(s)
17-Hydroxypregnenolone
Test ID
17OHP
General Information
Useful for:
As an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations in which a diagnosis of 21-hydroxylase and 11-hydroxylase deficiency have been ruled out
Confirming a diagnosis of 3-beta-hydroxy dehydrogenase (3-beta-HSD) deficiency
Analysis for 17-hydroxypregnenolone is also useful as part of a battery of tests to evaluate females with hirsutism or infertility; both can result from adult-onset CAH.
Specimen Type
Serum
Specimen Requirements
Red Top
Stability
Frozen (preferred) 28 days
Refrigerated 28 days
Unacceptable Specimen Conditions
Gross hemolysis OK
Gross lipemia OK
Gross icterus OK
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Estimated TAT
2-6 days
Testing Schedule
Monday, Tuesday, Thursday
CPT Code(s)
84143
Minimum Sample Volume
0.5 mL
Reference Range

CHILDREN
Males

Premature (26-28 weeks) 1,219-9,799 ng/dL
Premature (29-36 weeks) 346-8,911 ng/dL
Full term (1-5 months) 229-3,104 ng/dL
6 months-364 days 221-1,981 ng/dL
1-2 years 35-712 ng/dL
3-6 years <277 ng/dL
7-9 years <188 ng/dL
10-12 years <393 ng/dL
13-15 years 35-465 ng/dL
16-17 years 32-478 ng/dL

TANNER STAGES

Stage I <209 ng/dL
Stage II <356 ng/dL
Stage III <451 ng/dL
Stage IV-V 35-478 ng/dL

Females

Premature (26-28 weeks) 1,219-9,799 ng/dL
Premature (29-36 weeks) 346-8,911 ng/dL
Full term (1-5 months) 229-3,104 ng/dL
6 months-364 days 221-1,981 ng/dL
1-2 years 35-712 ng/dL
3-6 years <277 ng/dL
7-9 years <213 ng/dL
10-12 years <399 ng/dL
13-15 years <408 ng/dL
16-17 years <424 ng/dL

TANNER STAGES

Stage I <236 ng/dL
Stage II <368 ng/dL
Stage III <431 ng/dL
Stage IV-V <413 ng/dL

ADULTS
Males
> or =18 years: 55-455 ng/dL
Females
> or =18 years: 31-455 ng/dL

Performing Lab
Mayo
LOINC Code(s)
6765-2