Laboratory Services

AML (Acute myeloid leukemia) FISH Panel (Acute Promyelocytic Leukemia (APL))

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Updated Test Information:

Test Description
AML (Acute myeloid leukemia) FISH Panel (Acute Promyelocytic Leukemia (APL))


General Information

Probes: PML/RARA t(15;17), CBFB (inv(16), MLL (11q23), D7S486/CEP7, D20S108/CEP8, and RUNX1/RUNX1T1 t(8;21) (probes may be ordered separately)

Disease(s): Acute myeloid leukemia (AML), Acute Promyelocytic Leukemia (APL)

Specimen Requirements

Bone Marrow Aspirate and Peripheral Blood
2-5 mL Sodium Heparin tube (preferred) 
EDTA tube (acceptable)
Fixed-cell pellet from cytogenetic analysis slides with metaphase and/or interphase nuclei. (If sending slides please send at least 6 slides for testing)

Additional Processing Details

Transport to the testing lab at room temp is acceptable. Do not allow sample to overheat or freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen

Required Information

Complete the Incyte Diagnostics hematology requisition with the patient's demographics and relevant clinical history. Label the specimen containers with patient's full name, second unique identifier, and specimen site/source. Please provide a copy of the patient's complete blood count (CBC) report

Unacceptable Specimen Conditions

Specimen containers without two (2) patient identifiers, specimens submitted in inappropriate collection media, frozen specimens.

Department (code)



Fluorescence in-Situ Hybridization (FISH)

Estimated TAT

3-5 working days from receipt, can be ordered as a STAT result 24-48 hrs from receipt.

Testing Schedule



7 days after release of final report

CPT Code(s)

88377x6 manual

Additional Information

Clinical Significance: The AML panel identifies the most frequent cytogenetic abnormalities associated with favorable, intermediate, and poor risk AML/APL.

If Flow Cytometry studies are also being ordered, it is preferable to submit an EDTA (purple top) tube specifically for Flow Cytometry. if only one tube can be submitted, please submit one sodium heparin (green top) tube for both FISH and Flow Cytometry studies