Test Directory

Deamidated Gliadin Antibody, IgG

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Updated Test Information:

Test Description
Deamidated Gliadin Antibody, IgG
Synonym(s)

DGP, Celiac, Gliadin

Test ID
DGIGG
General Information

Deamidated gliadin peptides (DGP), one of the major protein components of gluten, have much higher diagnostic accuracy for celiac disease and dermatitis herpetiformis when compared to standard gliadin antibody serology. Patients with selective IgA deficiency may yield false negative DGP IgA results. Assay results should be used in conjunction with clinical findings and other serological tests. Antibodies directed against gliadin, its deamidated products, and tTG are dependent on the ingestion of gluten. For this reason, serology testing is best performed in patients on a gluten-containing diet.

Specimen Type

Serum

Alternate Specimen Type

Plasma (Li-Heparin, EDTA, or Citrate)

Specimen Requirements

Tiger

Additional Processing Details

Caution: Serum/plasma samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.

Stability

Stored at 22˚C: 8 hrs
Stored at 2-8˚C: 1 week
If assays are not completed within 1 week or the specimen is to be stored beyond 1 week, the serum/plasma should be frozen at or below -20˚C.

Unacceptable Specimen Conditions

Lipemic, hemolyzed or microbially contaminated samples.

Limitations

Antibodies directed against gliadin, its deamidated products, and tTG are dependent on the ingestion of gluten. For this reason, serology testing is best performed in patients on a gluten-containing diet.

Methodology

Fluorescent enzyme immunoassay (FEIA)

Estimated TAT

2-5 days

Testing Schedule

Monday-Saturday, alternating days

CPT Code(s)

83516

Minimum Sample Volume

1 mL

Pediatric Min. Volume (if applicable)

500 uL

Reference Range

Negative < 7 U/mL
Equivocal 7-10 U/mL
Positive > 10 U/mL

Performing Lab

Incyte Diagnostics

LOINC Code(s)

58710-5