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Deamidated Gliadin Antibody, IgG Updated!

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Updated Test Information:

  General Information
Last Updated Aug 05, 2020, 5:30 pm
Previous Value Deamidated gliadin peptides (DGP), one of the major protein components of gluten, have much higher diagnostic accuracy for celiac disease and dermatitis herpetiformis when compared to standard gliadin antibody serology. DGP IgG antibodies can be useful markers in patients with IgA deficiency. Assay results should be used in conjunction with clinical findings and other serological tests.
New Published Value Deamidated gliadin peptides (DGP), one of the major protein components of gluten, have much higher diagnostic accuracy for celiac disease and dermatitis herpetiformis when compared to standard gliadin antibody serology. Patients with selective IgA deficiency may yield false negative DGP IgA results. Assay results should be used in conjunction with clinical findings and other serological tests. Antibodies directed against gliadin, its deamidated products, and tTG are dependent on the ingestion of gluten. For this reason, serology testing is best performed in patients on a gluten-containing diet.
  Limitations
Last Updated Aug 05, 2020, 5:30 pm
Previous Value
New Published Value Antibodies directed against gliadin, its deamidated products, and tTG are dependent on the ingestion of gluten. For this reason, serology testing is best performed in patients on a gluten-containing diet.
Test Description
Deamidated Gliadin Antibody, IgG
Synonym(s)
DGP, Celiac, Gliadin
Test ID
DGIGG
General Information
Deamidated gliadin peptides (DGP), one of the major protein components of gluten, have much higher diagnostic accuracy for celiac disease and dermatitis herpetiformis when compared to standard gliadin antibody serology. Patients with selective IgA deficiency may yield false negative DGP IgA results. Assay results should be used in conjunction with clinical findings and other serological tests. Antibodies directed against gliadin, its deamidated products, and tTG are dependent on the ingestion of gluten. For this reason, serology testing is best performed in patients on a gluten-containing diet.
Specimen Type
Serum
Alternate Specimen Type
Plasma (Li-Heparin, EDTA, or Citrate)
Specimen Requirements
Tiger
Additional Processing Details
Caution: Serum/plasma samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.
Stability
Stored at 22˚C: 8 hrs
Stored at 2-8˚C: 48 hrs
If assays are not completed within 48 hrs or the specimen is to be stored beyond 48 hrs, the serum/plasma should be frozen at or below -20˚C.
Unacceptable Specimen Conditions
Lipemic, hemolyzed or microbially contaminated samples.
Limitations
Antibodies directed against gliadin, its deamidated products, and tTG are dependent on the ingestion of gluten. For this reason, serology testing is best performed in patients on a gluten-containing diet.
Methodology
Fluorescent enzyme immunoassay (FEIA)
Estimated TAT
2-5 days
Testing Schedule
Monday-Saturday, alternating days
CPT Code(s)
83516
Minimum Sample Volume
1 mL
Pediatric Min. Volume (if applicable)
500 uL
Reference Range
Negative < 7 U/mL
Equivocal 7-10 U/mL
Positive > 10 U/mL
Performing Lab
Incyte Diagnostics
LOINC Code(s)
58710-5