Test Directory

Diphtheria/Tetanus Antibody Panel, Serum

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Updated Test Information:

Test Description
Diphtheria/Tetanus Antibody Panel, Serum

Anti-tetanus toxoid; C. tetani; Clostridium tetani; Corynebacterium diphtheriae Antitoxin; Diphtheria Antitoxoid; Tetanus Immune Response; Tetanus toxoid antibodies; Tetanus/Diphtheria Antibody Panel

Test ID
General Information

Useful for:

  • Assessment of an antibody response to tetanus and diphtheria toxoid vaccines, which should be performed at least 3 weeks after immunization

  • Aids in the evaluation of immunodeficiency

  • This test should not be used to diagnose tetanus infection

Specimen Type


Specimen Requirements

  • Preferred: Serum Gel

  • Acceptable: Red Top


  • Refrigerated (preferred):30 days

  • Frozen: 30 days

Unacceptable Specimen Conditions

  • Gross hemolysis

  • Gross lipemia

  • Gross icterus

  • Heat Inactivated specimen


  • This assay does not provide diagnostic proof of lack of protection again diphtheria or the presence of absence of immunodeficiency. Results must be confirmed by clinical findings and other serological tests

  • The diagnosis of tetanus is by clinical observation. A positive wound culture for the agent of tetanus, Clostridium tetani, may support, but does not confirm, the diagnosis. Toxin assays for tetanospasmin may be useful but are only available in a few laboratories

  • The results obtained from this assay are not diagnostic proof of lack of protection against tetanus or the presence or absence of immunodeficiency


Enzyme Immunoassay (EIA)

Estimated TAT

1-4 days

Testing Schedule


Test Includes

  • Diphtheria IgG Ab

  • Diphtheria IgG Value

  • Tetanus IgG Ab

  • Tetanus IgG Value


14 days

CPT Code(s)


Additional Information
Minimum Sample Volume

0.8 mL

Reference Range
Assay Patient Status Interpretation (IU/mL)
DIPHTHERIA TOXOID IgG ANTIBODY Vaccinated Positive (≥ 0.01)
Unvaccinated Negative (< 0.01)
TETANUS TOXOID IgG ANTIBODY Vaccinated Positive (≥ 0.01)
Unvaccinated Negative (< 0.01)
Performing Lab


LOINC Code(s)

33469-8, 45166-6, 48654-8, 53935-3