Test Directory

dsDNA Antibody

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Updated Test Information:

Test Description
dsDNA Antibody
Double stranded DNA, ANA, Antinuclear Antibodies, Anti-DNA
Test ID
General Information
dsDNA antibodies are a disease specific serological marker for the diagnosis and disease management of patients with systemic lupus erythematosus (SLE). More than 90% of sera from patients with active SLE contain dsDNA antibodies. Smaller amounts may be present in patients with other rheumatic disorders, chronic active hepatitis, infectious mononucleosis, and biliary cirrhosis. Assay results should be used in conjunction with clinical findings and other serological tests.
Specimen Type
Alternate Specimen Type
Plasma (Li-Heparin, EDTA, or Citrate)
Specimen Requirements
Additional Processing Details
Caution: Serum/plasma samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.
Stored at 22˚C: 8 hrs
Stored at 2-8˚C: 48 hrs
If assays are not completed within 48 hrs or the specimen is to be stored beyond 48 hrs, the serum/plasma should be frozen at or below -20˚C.
Unacceptable Specimen Conditions
Lipemic, hemolyzed or microbially contaminated samples.
Fluorescent enzyme immunoassay (FEIA)
Estimated TAT
2-5 days
Testing Schedule
Monday-Saturday, alternating days
CPT Code(s)
Minimum Sample Volume
1 mL
Pediatric Min. Volume (if applicable)
500 uL
Reference Range
Negative < 10 IU/mL
Equivocal 10-15 IU/mL
Positive > 15 IU/mL
Performing Lab
Incyte Diagnostics
LOINC Code(s)