EGFR Mutation AnalysisPrint this page
Updated Test Information:
EGFR Mutation Analysis
EGFR, epidermal growth factor receptor
Bi-directional sequencing of exons 18-21 of the EGFR gene for detection of EGFR-activating mutations and TKI resistance mutations (including T790M) in these exons. Tumor enrichment is performed before extraction.
EGFR mutation analysis is recommended in non-small cell lung carcinoma (NSCLC) to detect mutations (commonly L858R and exon 19 deletions) associated with increased sensitivity to EGFR tyrosine kinase inhibitors. Detection of TKI resistance mutations such as T790M in patients being treated with a TKI is useful for planning alternate treatment.
FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at
Complete the Incyte Diagnostics requisition with the patient's demographics, ordering physician, and a copy of the pathology report.
Use cold pack for transporting block during summer to prevent block from melting. Slides can be packed at room temperature
Extracted DNA is kept for 30 days