Test Directory

FibroTest-ActiTest, Serum

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Updated Test Information:

Test Description
FibroTest-ActiTest, Serum
Synonym(s)
FibroTest-ActiTest
Test ID
FIBRO
General Information
Useful for:
Evaluating hepatic fibrosis in chronic hepatitis C patients
Diagnosing fibrosis in carriers of chronic hepatitis B virus
Evaluating hepatic fibrosis in co-infected HIV carriers
Providing access to new-generation noninterferon treatment for hepatitis
Evaluating fibrosis in patients suffering from metabolic conditions (nonalcoholic fatty liver disease) and patients who consume excess alcohol
Specimen Type
Serum
Specimen Requirements
SST
Specimen Collection / Processing Instructions
SST - 1.Centrifuge and aliquot within 2 hours of collection. 2.Centrifuged serum must be light protected within 4 hours of collection. It is acceptable to draw the blood and then protect it from light after centrifugation as long as it is within 4 hours of collection.
Stability
Refrigerated (preferred) 7 days LIGHT PROTECTED CONTAINER
Frozen 14 days LIGHT PROTECTED CONTAINER
Ambient 24 hours LIGHT PROTECTED CONTAINER
Unacceptable Specimen Conditions
Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Other Patients <2 years of age
Methodology
INTF: Algorithm and interpretation provided through BioPredictive.
APOAF: Automated Turbidimetric Immunoassay
A2MF: Nephelometry
HAPTF: Nephelometry
ALTF: Photometric Rate, L-Alanine with Pyridoxal-5-Phosphate
GGTF: Photometric Rate
TBILF: Photometric, Diazonium Salt (DPD)
Estimated TAT
1-3 days
Testing Schedule
Monday-Saturday
Test Includes
INTF FibroTest-ActiTest
APOAF Apolipoprotein A1
A2MF Alpha-2-Macroglobulin
HAPTF Haptoglobin
ALTF Alanine Aminotransferase (ALT)
GGTF Gamma Glutamyltransferase (GGT)
TBILF Bilirubin, Total
CPT Code(s)
81596
Minimum Sample Volume
1.5 mL
Reference Range
FibroTest Score Stage Interpretation
0.00-0.21* F0 No fibrosis
0.21-0.27* F0-F1 No fibrosis
0.27-0.31* F1 Minimal fibrosis
0.31-0.48* F1-F2 Minimal fibrosis
0.48-0.58* F2 Moderate fibrosis
0.58-0.72* F3 Advanced fibrosis
0.72-0.74* F3-F4 Advanced fibrosis
0.74-1.00 F4 Severe fibrosis (Cirrhosis)

*Boundary values can apply to 2 stages based on rounding. For example, a FibroTest score of 0.305 will round up to 0.31 and be staged F1. A FibroTest score of 0.314 will round down to 0.31 and be staged F1-F2.

ActiTest Score Grade Interpretation
0.00-0.17* A0 No activity
0.17-0.29* A0-A1 No activity
0.29-0.36* A1 Minimal activity
0.36-0.52* A1-A2 Minimal activity
0.52-0.60* A2 Significant activity
0.60-0.62* A2-A3 Significant activity
0.62-0.100 A3 Severe activity

*Boundary values can apply to 2 grades based on rounding. For example, an ActiTest score of 0.285 will round up to 0.29 and be graded A0-A1. An ActiTest score of 0.294 will round down to 0.29 be graded A1.

ALPHA-2-MACROGLOBULIN
100-280 mg/dL

ALANINEAMINOTRANSFERASE (ALT)
Males:
<12 months: No established reference values
> or =1 year: 7-55 U/L

Females:
<12 months: No established reference values
> or =1 year: 7-45 U/L

APOLIPOPROTEIN A1
Males:
<24 months: No established reference values
2-17 years:
Low: <115 mg/dL
Borderline low: 115-120 mg/dL
Acceptable: >120 mg/dL
> or =18 years: > or =120 mg/dL

Females:
<24 months: No established reference values
2-17 years:
Low: <115 mg/dL
Borderline low: 115-120 mg/dL
Acceptable: >120 mg/dL
> or =18 years: > or =140 mg/dL

GAMMA-GLUTAMYLTRANSFERASE (GGT)
Males:
0-11 months: <178 U/L
12 months-6 years: <21 U/L
7-12 years: <24 U/L
13-17 years: <43 U/L
> or =18 years: 8-61 U/L

Females:
0-11 months: <178 U/L
12 months-6 years: <21 U/L
7-12 years: <24 U/L
13-17 years: <26 U/L
> or =18 years: 5-36 U/L

HAPTOGLOBIN
30-200 mg/dL

BILIRUBIN, TOTAL
0-6 days: Refer to www.bilitool.org for information on age-specific (postnatal hour of life) serum bilirubin values.
7-14 days: <15.0 mg/dL
15 days to 17 years: < or =1.0 mg/dL
> or =18 years: < or =1.2 mg/dL

Performing Lab
Mayo
LOINC Code(s)
1975-2, 1743-4, 1835-8, 1869-7, 2324-2, 46127-7, 48795-9, 48794-2, 88447-8, 48792-6, 48793-4, 88448-6, 48767-8, 74715-4