Laboratory Services

Metanephrines, Fractionated, Free, Plasma

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Updated Test Information:

Test Description
Metanephrines, Fractionated, Free, Plasma

UOW2604, Fractionated Metanephrines-Plasma, Free Metanephrines-Plasma, MEN, MEN IIA, MEN IIB, Multiple Endocrine Neoplasia, Neuroendocrine, NMN (Normetanephrines)-plasma, paraganglioma, Phaeochromocytoma, Pheochromocytoma, Soft-PMET

Test ID
General Information

The most sensitive test to rule-out pheochromocytoma is plasma free metanephrines (PLMET). See also Metanephrines, Fractionated, Urine (RUFMET). For a recent review of the biochemical diagnosis of pheochromocytoma, see Pacak K et al. Nature Clin Pract Endocrinol Metab 2007; 3:92-102.PMID: 17237836

The concentration of metanephrine and normetanephine is determined by solid phase extraction followed by liquid chromatography-tandem mass spectrometry. The reportable range is 0.2 to 80.0 nmol/L for metaneprhine and normetaneprhine, respectively, with imprecision between 3.3 and 8.2 %CV.

Container Type

 3mL blood in a LAVENDER TOP (EDTA) tube

Specimen Type


Specimen Requirements

1.5 mL EDTA plasma

Specimen Collection / Processing Instructions

Centrifuge & remove plasma - Freeze in plastic aliquot tube at -20˚C.

Minimum Sample Volume

0.5 mL EDTA plasma

Department (code)

Chemistry, University


Serum solid phase extraction. Isotope dilution liquid chromatography mass spectrometry

Testing Schedule


Test Includes

MN                  Metanephrine
NMN              Normetanephrine
PLMETM      Metanephrines Method, Plasma

CPT Code(s)


STAT Orderable (Y/N)


Performing Lab


LOINC Code(s)