Laboratory Services

Methylmalonic Acid, Quantitative, Serum

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Updated Test Information:

Test Description
Methylmalonic Acid, Quantitative, Serum
Synonym(s)

B12 Deficiency; CblC; Cobalamin Deficiency; Methylmalonate; Methylmalonic Acid (MMA); MMA (Methylmalonic Acid); Methylmalonic Aciduria

Test ID
MMAS
General Information

Useful for:



  • Evaluating children with signs and symptoms of methylmalonic acidemia

  • Evaluating individuals with signs and symptoms associated with a variety of causes of cobalamin (vitamin B12) deficiency

Specimen Type

Serum

Specimen Requirements

  • Preferred: Red Top

  • Acceptable: Serum Gel (SST)

Stability

  • Refrigerated (preferred): 48 days

  • Ambient: 48 days

  • Frozen: 48 days

Limitations

Diet, nutritional status, and age should be considered in the evaluation of serum or urine methylmalonic acid level

Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Estimated TAT

3-5 days

Testing Schedule

Monday-Friday

Retention

7 days

CPT Code(s)

83921

Additional Information
Minimum Sample Volume

0.5 mL

Reference Range

≤ 0.40 nmol/mL

Performing Lab

Mayo

LOINC Code(s)

13964-2