Laboratory Services

Nicotine and Metabolites, Serum

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Updated Test Information:

Test Description
Nicotine and Metabolites, Serum
Synonym(s)

Cotinine; Tobacco Alkaloids

Test ID
NICOS
General Information

Useful for monitoring tobacco use

Specimen Type

Serum

Specimen Requirements

Red Top

Stability

  • Refrigerated (preferred): 28 days

  • Ambient: 28 days

  • Frozen: 28 days

Limitations

Knowledge of time elapsed between last dose and specimen collection is important for interpretation of test results

Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Estimated TAT

2-4 days

Testing Schedule

Monday-Saturday

Test Includes

  • Nicotine

  • Cotinine

Retention

2 weeks

CPT Code(s)

80323

Additional Information
Minimum Sample Volume

0.5 mL

Reference Range

  • NICOTINE: <3.0 ng/mL

  • COTININE: <3.0 ng/mL

Performing Lab

Mayo

LOINC Code(s)

3853-9, 10365-5