Laboratory Services

Protein C Activity

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Updated Test Information:

Test Description
Protein C Activity
Synonym(s)

UOW883, Protein C Level

Test ID
PCCLOT
General Information

Protein C Activity is a quntitative determination of the functional protein C level in plasma by the synthetic chromogenic substrate method. This assay is insensitive to hemoglobin (up to 2 g/l), bilirubin (up to 200 mg/l) and triglycerides (up to 4 g/l). PIVKA protein C (PIVKA: protein induced by vitamin K antagonists) present in the plasma of patients receiving oral anticoagulant therapy may be measured by the colorimetric method. Patients on warfarin therapy may see decrease in protein C activity because of the vitamin K antagonistic effect of the drug. Protein C is a vitamin K dependent factor. The presence of aprotinin in the plasma may result in an underestimation of the protein C level.


Outside clients should fill and submit Coagulation Patient Clinical History Form

Container Type

3 or 5 mL Blue Top (CITRATE) tube

Specimen Type

Plasma

Specimen Collection / Processing Instructions

Centrifuge for 10 minutes, remove plasma & re-spin plasma for another 10 minutes. Decant & Freeze plasma (minimum 1.0 mL) @ -20°C to -80°C. Send frozen on dry


The Laboratory MUST process specimen, within 4 hrs of blood collection.

Department (code)

Coagulation

Methodology

Stago STA Stachrom Protein C

Testing Schedule

Monday, Thursday

CPT Code(s)

85303

Reference Range

Units: % 


Male/Female


0-29d           20-150


1m-2m        21-150


3m-5m        28-150


6m-11m     37-150


1y-5y           40-150


6y-9y          45-150


10y -            65-150  


Effective date: 07/01/2004


Elevated Protein C is not associated with thrombosis or bleeding.

STAT Orderable (Y/N)

No

Performing Lab

UW

LOINC Code(s)
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