Test Directory

Quad Screen (Second Trimester) Maternal, Serum

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Updated Test Information:

Test Description
Quad Screen (Second Trimester) Maternal, Serum
Synonym(s)
QUAD SCRN (2nd Tri) Maternal
Test ID
QUAD1
General Information
Useful for:
Prenatal screening for open neural tube defect (alpha-fetoprotein only), trisomy 21 (alpha-fetoprotein, human chorionic gonadotropin, estriol, and inhibin A) and trisomy 18 (alpha-fetoprotein, human chorionic gonadotropin, and estriol)
Specimen Type
Serum
Specimen Requirements
SST
Additional Processing Details
0.75 mL
Stability
Refrigerated (preferred) 7 days
Frozen 90 days
Unacceptable Specimen Conditions
Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK
Methodology
Immunoenzymatic Assay
Estimated TAT
1-4 days
Testing Schedule
Monday-Friday
CPT Code(s)
81511
Reference Range

NEURAL TUBE DEFECTS
An AFP multiple of the median (MoM) <2.5 is reported as screen negative. AFP MoMs > or =2.5 (singleton and twin pregnancies) are reported as screen positive.

DOWN SYNDROME
Calculated screen risks <1/270 are reported as screen negative, risks > or =1/270 are reported as screen positive.

TRISOMY 18
Calculated screen risks <1/100 are reported as screen negative, risks > or =1/100 are reported as screen positive.

An interpretive report will be provided.

Performing Lab
Mayo
LOINC Code(s)
32399-8, 32399-8, 43995-0, 49090-4, 43994-3, 48803-1, 83073-7, 23811-3, 23811-3, 2250-9, 21264-7, 83086-9, 23841-0, 36904-1, 2478-6, 49092-0, 80615-8, 48767-8, 33882-2, 21112-8, 43993-5, 29463-7, 29463-7, 44877-9, 21484-1, 64234-8, 11781-2, 11888-5, 11779