Test Directory

Renin Activity, Plasma

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Updated Test Information:

Test Description
Renin Activity, Plasma
Synonym(s)
PRA (Plasma Renin Activity)
Test ID
PRA
General Information
Useful for:
Investigation of primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome)
Specimen Type
Plasma
Specimen Requirements
Lavender
Additional Processing Details
1. Draw blood in a chilled syringe from a patient in a seated position; place specimenin a chilled, lavender-top
(EDTA) tube; and mix.
2. Alternatively, draw blood directly in a chilled, lavender top (EDTA) tube.
3. Immediately place EDTA tube into an ice-water bath until thoroughly cooled.
4. Refrigerate specimen during centrifugation and immediately transfer plasmato plastic vial. (If a refrigerated
centrifuge is unavailable, chill the centrifuge carriers. Centrifuge specimen for< or =5 minutes, then promptly transfer plasma.)
5. Immediately freeze plasma.
Stability
Plasma EDTA Frozen 14 days
Unacceptable Specimen Conditions
Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK
Limitations
Angiotensin converting enzyme (ACE) inhibitors have the potential to "falsely elevate" PRA. Therefore, in a patient
treated with an ACE-inhibitor, the findings of a detectable PRA level or a low SA:PRA ratio do not exclude the
diagnosis of primary aldosteronism. In addition, a strong predictor for primary aldosteronism is a PRA level
undetectably low in a patient taking an ACE-inhibitor.
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Estimated TAT
2 days
Testing Schedule
Monday through Friday; 1 p.m.
CPT Code(s)
84244
Minimum Sample Volume
1.15 mL
Reference Range
Age Mean Range
0-2 years 4.6 ng/mL/hour 1.4-7.8 ng/mL/hour
3-5 years 2.5 ng/mL/hour 1.5-3.5 ng/mL/hour
6-8 years 1.4 ng/mL/hour 0.8-2.0 ng/mL/hour
9-11 years 1.9 ng/mL/hour 0.9-2.9 ng/mL/hour
12-17 years 1.8 ng/mL/hour 1.2-2.4 ng/mL/hour

Mean data not standardized as to time of day or diet. Infants were supine, children sitting.

Na-depleted, upright (peripheral vein specimen)
18-39 years: 10.8 ng/mL/hour (mean)
2.9-24.0 ng/mL/hour (range)
> or =40 years: 5.9 ng/mL/hour (mean)
2.9-10.8 ng/mL/hour (range)

Na-replete, upright (peripheral vein specimen)
18-39 years: 1.9 ng/mL/hour (mean)
< or =0.6-4.3 ng/mL/hour (range)
> or =40 years: 1.0 ng/mL/hour (mean)
< or =0.6-3.0 ng/mL/hour (range)

Performing Lab
Mayo
LOINC Code(s)
2915-7