Laboratory Services

Small B-Cell Lymphoma (LBCL), Low Grade

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Updated Test Information:

Test Description
Small B-Cell Lymphoma (LBCL), Low Grade
Synonym(s)

SBCL, Low Grade B-Cell Lymphoma, NHL, MCL. MZL. MALT, Follicular lymphoma

General Information

Probes: BCL6 (3q27.3q28), BCL2 (18q21.33), IGH (14q32.33)/CCND1(11q13.3), MALT1 (18q21.31q21.32) (probe sets may be ordered separately)


Disease(s): NHL, B-Cell lymphoma, Mantle Cell lymphoma (MCL), Follicular Lymphoma, Marginal zone lymphoma (MZL), MALT lymphoma

Specimen Requirements

Bone Marrow Aspirate and Peripheral Blood
2-5 mL Sodium Heparin tube (preferred)
EDTA tube (acceptable)


Fixed-cell pellet from cytogenetic analysis slides with metaphase and/or interphase nuclei. (If sending slides please send at least 6 slides for testing)

Additional Processing Details

Transport to the testing lab at room temp is acceptable. Do not allow sample to overheat or freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen

Required Information

Complete the Incyte Diagnostics hematology requisition with the patient's demographics and relevant clinical history. Label the specimen containers with patient's full name, second unique identifier, and specimen site/source. Please provide a copy of the patient's complete blood count (CBC) report.

Unacceptable Specimen Conditions

Specimen containers without two (2) patient identifiers, specimens submitted in inappropriate collection media, frozen specimens.

Department (code)

FISH

Methodology

Fluorescence in-Situ Hybridization (FISH)

Estimated TAT

3-5 working days from receipt

Testing Schedule

Monday-Friday

Retention

7 days after release of final report

CPT Code(s)

88377x4 manual

Additional Information

Clinical Significance: This targeted panel is appropriate when clinical and morphologic evaluation is most suggestive of a low-grade/small B-cell lymphoma, and high-grade lymphomas. BCL6 evaluation can provide further prognostic information in cases of follicular lymphoma since it can indicate a higher risk for transformation to aggressive lymphoma. Low-grade/small B-cell lymphomas include follicular lymphoma, mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL)/MALT lymphomas.

If Flow Cytometry studies are also being ordered, it is preferable to submit an EDTA (purple top) tube specifically for Flow Cytometry. If only one tube can be submitted, please submit one sodium heparin (green top) tube for both FISH and Flow Cytometry studies

Performing Lab

Incyte Diagnostics