Laboratory Services

Small B-Cell Lymphoma (LBCL), Low Grade

Name: Incyte Diagnostics
Address: 13103 E Mansfield Ave, Spokane Valley, Washington, 99216, USA
Telephone: +1-If-you-have-questions-regarding-your-bill-or-would-like-to-make-a-payment,-please-visit-our-Billing-page-by-clicking-"Pay-Online"-at-the-top-of-the-page-For-other-inquiries,-please-call-us-at-509-892-2700

Updated Test Information:

Test Description	Small B-Cell Lymphoma (LBCL), Low Grade
Synonym(s)	SBCL, Low Grade B-Cell Lymphoma, NHL, MCL. MZL. MALT, Follicular lymphoma
General Information	Probes: BCL6 (3q27.3q28), BCL2 (18q21.33), IGH (14q32.33)/CCND1(11q13.3), MALT1 (18q21.31q21.32) (probe sets may be ordered separately) Disease(s): NHL, B-Cell lymphoma, Mantle Cell lymphoma (MCL), Follicular Lymphoma, Marginal zone lymphoma (MZL), MALT lymphoma
Specimen Requirements	Bone Marrow Aspirate and Peripheral Blood 2-5 mL Sodium Heparin tube (preferred) EDTA tube (acceptable) Formalin fixed paraffin embedded (FFPE) tissue blocks or 2 unstained slides (4-5 microns thick sections) 1 H&E slide for pathology review (required) Fixed-cell pellet from cytogenetic analysis slides with metaphase and/or interphase nuclei. (If sending slides please send at least 6 slides for testing)
Additional Processing Details	Transport to the testing lab at room temp is acceptable. Do not allow sample to overheat or freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen
Required Information	Complete the Incyte Diagnostics hematology requisition with the patient's demographics and relevant clinical history. Label the specimen containers with patient's full name, second unique identifier, and specimen site/source. Please provide a copy of the patient's complete blood count (CBC) report.
Unacceptable Specimen Conditions	Specimen containers without two (2) patient identifiers, specimens submitted in inappropriate collection media, frozen specimens.
Department (code)	FISH
Methodology	Fluorescence in-Situ Hybridization (FISH)
Estimated TAT	Heme samples: 3-5 working days from receipt FFPE samples: 4-7 working days from receipt
Testing Schedule	Monday-Friday
Retention	Heme samples: 7 days after release of final report FFPE Samples: Blocks:10 years H&E and IHC Slides: 10 years IF Slides: 30 days
CPT Code(s)	88377x4 manual
Performing Lab	Incyte Diagnostics
Additional Information	Clinical Significance: This targeted panel is appropriate when clinical and morphologic evaluation is most suggestive of a low-grade/small B-cell lymphoma, and high-grade lymphomas. BCL6 evaluation can provide further prognostic information in cases of follicular lymphoma since it can indicate a higher risk for transformation to aggressive lymphoma. Low-grade/small B-cell lymphomas include follicular lymphoma, mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL)/MALT lymphomas. If Flow Cytometry studies are also being ordered, it is preferable to submit an EDTA (purple top) tube specifically for Flow Cytometry. If only one tube can be submitted, please submit one sodium heparin (green top) tube for both FISH and Flow Cytometry studies