Laboratory Services

Tacrolimus by LC-MS/MS

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Updated Test Information:

Test Description
Tacrolimus by LC-MS/MS

UOW2752, F506, FK506, PROGRAF, TACRO

Test ID
General Information

The concentration of tacrolimus in whole blood is determined by liquid chromatography-tandem mass spectrometry after protein precipitation. The reportable range is 1.0 to 195.0 ng/mL with imprecision between 4 and 7 %CV.

Container Type

3 mL blood in a LAVENDER TOP tube. Trough specimen preferred.

Specimen Type

Whole blood

Specimen Collection / Processing Instructions

Refrigerate whole blood, do not spin Frozen sample acceptable - Do not repeat freeze-thaw cycle

Minimum Sample Volume

1.5 mL whole blood for 3 mL Lavender Liquid EDTA (K3 EDTA); 0.5 mL whole blood for 3 mL Lavender Dry EDTA (K2 EDTA)


Room temperature - 2 Days

Refrigerated - 5 Days

Department (code)

Chemistry, University


Whole blood protein precipitation. Analysis by liquid chromatography - tandem mass spectrometry.

Testing Schedule


Test Includes

TACRO      Tacrolimus by LCMSMS
TACINF     Tacrolimus Information

CPT Code(s)


STAT Orderable (Y/N)


Performing Lab


LOINC Code(s)